## Description of contents ##
This repository contains data and code (hosted on [Github][1]) for the manuscript *Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes* by Anne K. Bozack et al. available at [https://doi.org/10.1186/s12940-021-00754-7][2].
The organization of the repository is as follows:
- The ***bangladesh-study*** folder contains the scripts and results associated with the Bangladesh DNAm studies.
- The ***chile-study directory*** is made up of subdirectories containing the code and results associated with the buccal cell and the PBMC DNAm analyses. It also holds a directory with notebooks assessing the within-participant buccal-PBMC sample similarities, and a directory with a notebook of descriptive statistics used to create Table 1 in the accompanying paper.
- The ***DMR-meta-analysis*** folder contains the DMR-meta-analysis.Rmd notebook, which details the meta-analysis procedure and summarized the results output by comb-p.
- The ***helper-scripts*** directory contains multiple helper files used to perform the analyses described in the paper.
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#### Schematic of Data Processing and Analysis Pipeline ####
![Schematic of the Data Processing and Analysis Pipeline][3]
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#### Citation: ####
Bozack AK, Boileau P, Wei L, et al. 2021. Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes. Environ Health. 2021 Jul 9;20(1):79. doi: 10.1186/s12940-021-00754-7. [PMID: 34243768][4]
[1]: https://github.com/annebozack/SRP_arsenic_DNAm_metaanalysis
[2]: https://doi.org/10.1186/s12940-021-00754-7
[3]: https://raw.githubusercontent.com/annebozack/images/master/analysis_flowchart_sm.png
[4]: https://pubmed.ncbi.nlm.nih.gov/34243768/