**Figure 1**. **Tumor xenograft experiment testing efficacy of cimetidine in inhibiting the growth of tumors in SCID mice**. Number of mice: (**A**) A549 tumors: n=14 (vehicle), n=13 (cimetidine), n=4 (doxorubicin) (**B**) ACHN tumors: n=15 (vehicle), n=15 (cimetidine). Two-tailed Welch’s *t*-test on Day 11 relative volumes between vehicle or doxorubicin treated A549 tumors; *t* (6.73) = 2.68, uncorrect *p* = .0325 with *a priori* alpha level = .0167; (Bonferroni corrected *p* = .0976). Two-way ANOVA interaction between cell line (A549 or ACHN) and treatment (vehicle or cimetidine) on natural log transformed Day 11 relative volumes; *F* (1,53) = 3.88, *p* = .054. Pairwise contrast between A549 tumors treated with vehicle or cimetidine; *t* (53) = 2.16, uncorrected *p* = .035 with *a priori* alpha level = .0167; (Bonferroni corrected *p* = .105). Pairwise contrast between ACHN tumors treated with vehicle or cimetidine; *t* (53) = -0.58, uncorrected *p* = .562 with *a priori* alpha level = .0167; (Bonferroni corrected *p* > .99).
Access [data processing script][1] and [analysis script][2] for the statistical tests related to this figure. This script will call the [data][3] directly from the OSF.
<br>
**Figure 2**. **Final tumor weights from xenograft experiment testing efficacy of cimetidine in inhibiting the growth of tumors in SCID mice**. Number of mice: A549 tumors: n=14 (vehicle), n=13 (cimetidine), n=4 (doxorubicin). ACHN tumors: n=15 (vehicle), n=15 (cimetidine). Two-tailed Welch’s *t*-test between vehicle or doxorubicin treated A549 tumors; *t* (4.078) = 0.771, *p* = .483. Two-way ANOVA interaction between cell line (A549 or ACHN) and treatment (vehicle or cimetidine); *F* (1,53) = 0.00005, *p* = .994. Two-way ANOVA main effect of cell line (A549 or ACHN); *F* (1,53) = 7.56, *p* = .00814.
Access [analysis script][5] for the statistical tests related to this figure. This script will call the [data][6] directly from the OSF.
[1]: https://osf.io/6vyr4/
[2]: https://osf.io/7wph8/
[3]: https://osf.io/xcuh6/files/
[4]: https://osf.io/uycqr/
[5]: https://osf.io/pkjhs/
[6]: https://osf.io/bqe5c/
