A COMPUTATIONAL STUDY OF ASTROCYTIC CALCIUM HOMEOSTASIS IN THE SYNAPTIC CLEFT

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Category: Hypothesis

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Introduction: Calcium (Ca2+) contributes to long-term and short-term synaptic plasticity in many ways and Ca2+ concentrations within the synaptic cleft fluctuate drastically during neuronal activity. Delivery of Ca2+ to the synaptic cleft can be regulated by astrocytes through transporters in their peripheral processes, e.g. through NCX and PMCA. Therefore, astrocytes may affect synaptic plasticit...

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