## Data Guide ##
This repository contains the data utilized in the publication "Persistent Homology for the Quantitative Evaluation of Architectural Features in Prostate Cancer Histology".
Data comprises 5,182 regions of interest (ROIs) derived from radical prostatectomy cases at Tulane Medical Center under an approved IRB. Specimens were digitized utilizing a digital whole slide scanner (Aperio CS2) at 20x magnification with 0.5 μm per pixel resolution. The resultant whole slide images (WSI’s) were scored manually by an expert genitourinary pathologist at the Tulane University School of Medicine, with regions corresponding to purely graded tumor content outlined by hand in the Leica ImageScope software package. The corresponding annotations were extracted manually and divided into 512x512 pixel ROIs (corresponding to 256x256 μm2 regions) of pure Gleason grade 3, 4, or 5. Details of the ROI label schema and grade labels are included in the Data Dictionary in the attached Project Wiki.
If you publish using our data please cite our work: Lawson, P., Sholl, A. B., Brown, J. Q., Fasy, B. T. & Wenk, C. Persistent Homology for the Quantitative Evaluation of Architectural Features in Prostate Cancer Histology. Scientific Reports 9, 1139 (2019). https://doi.org/10.1038/s41598-018-36798-y
