In previous research we found that individuals with a negative religious coping style and individuals with an anxious attachment style to God perceived a target object as heavier than did individuals with a positive religious coping style or a secure attachment style. Additionally, we found that perception of object weight, a perception we hypothesize to be an indicator of psychological burden, and religious coping are important factors in the association between self-reported hassles that accompany relationship stress and self-reported hassles related to health outcomes. We have argued that these findings point to important mediating variables in the relationship between stress and health. The current study expanded this research by examining the relationship between self-reported levels of stress and self-reported measures of physical health and depression symptoms, as mediated by indicators of religious and spiritual conflict (RSC) and indicators of psychological burden (PB). Indicators of religious and spiritual conflict included the Religious and Spiritual Struggles Scale, Religious Coping, and Attachment to God Scale. Indicators of psychological burden included an object weight perception task, and a visual priming task assessing avoidance sensitivity to aversive stimuli. We found that measures of RSC and PB mediate the relationship between perceived levels of stress and physical and psychological health outcomes. We argue that it is important to consider the impact of both religious struggle and the weight of other psychological burdens in considering the complex relationship between stress and health. Destiny Brooks, M.S. Graduate Student, Experimental Psychology Research Strategist Intern, Office of the Vice President of Research