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Description: d-MedBioclim is a newly developed dataset for the Euro-Mediterranean region. This dataset applies the delta-change method by comparing the values of 25 General Circulation Models (GCMs) for the reference period (1981–2010) with their projections for future periods (2026–2050, 2051–2075, and 2076–2100) under the SSP1-RCP2.6, SSP2-RCP4.5, and SSP5-RCP8.5 scenarios. These anomalies are added to two pre-existing datasets, ERA5-Land and CHELSA, yielding resolutions of 0.1º and 0.01º, respectively. Additionally, this manuscript provides a ranking of GCMs for each major river basin within the study area to guide model selection. d-MedBioclim includes, for all the aforementioned scenarios, monthly mean temperature, total monthly precipitation, and 23 bioclimatic variables, including 9 (biorm1 to biorm9) from the Worldwide Bioclimatic Classification System (WBCS) that are not available in other databases. It also provides two climate classifications: Köppen-Geiger and WBCS. This dataset is expected to be a valuable resource for modeling the distribution of Mediterranean species, which are highly affected by climate change. The dataset can be dowloaded from: http://dx.doi.org/10.71831/8nzk-3889