# Description of contents This repository contains the necessary scripts used in the analysis of Bozack et al.'s "Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of twelve metals" available at <a href="https://doi.org/10.1186/s13148-021-01198-z">doi.org/10.1186/s13148-021-01198-z</a>. The organization of the repository is as follows: - <b>EWAS functions.R:</b> functions including plotting and wrapper functions for analyses of DMPs and DMRs. This scrpt also contains a modified version of the combp function to exclude DMRs consisting of one probe - <b>viva_DNAm_metals_dataProcessing_descriptiveStats.rmd:</b> Processing and descriptive statistics for cord blood DNAm data - <b>viva_DNAm_metals_dataProcessing_descriptiveStats.rmd:</b> Processing and descriptive statistics for mid-childhood DNAm data - <b>viva_DNAm_metals_cordblood_DMPs_DMRs_smk.rmd:</b> EWAS and DMR analysis for cord blood DNAm data - <b>viva_DNAm_metals_age7_DMPs_DMRs_smk.rmd:</b> EWAS and DMR analysis for mid-childhood DNAm data - <b>EWAS_results folder:</b> Complete output of cord blood adjusted EWAS for all metals