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Description: Visual Word Recognition is constrained by writing systems. The Orthographic Depth Hypothesis was proposed to account for phonological activation in various degrees depending on how transparent the grapheme-phoneme-conversion rule is in a writing system. This current study extends the investigation of ODH in Bilingualism to understand the cross-language cognitive processes in bi-script readers. In two cross-language masked priming experiments, we show asymmetrical cognate facilitation effects, which are typically reported as a result of shared phonology or/and orthography between languages, in addition to meaning equivalence. That is, with the same set of items, when the primes were Chinese and the targets English (Experiment 1), there was no cognate facilitation effect; however, when we switched the languages in prime-target pairs (Experiment 2), the cognate facilitation effects emerged. These results indicate that shared phonology across languages is not sufficient to induce cognate facilitation effects and that language-dependent processing mechanisms play a crucial role.