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Replication Studies  /

Contributors:
  1. Irawati Kandela
  2. Fraser Aird
Affiliated institutions: Center For Open Science

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Category: Project

Description: Replication of "Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data”. Includes information to prepare the replication experiments. Includes data, code, and digital materials from completed replication experiments.

License: CC-By Attribution 4.0 International

Study 21: Replication of Sirota et al., 2011 (Science Translational Medicine) | Discussion
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Type: Individual replications
Status: Fully completed


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Replication Study: Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data


**Abstract:**

In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015), that described how we intended to replicate selected experiments from the paper “Discovery and Preclinical Validation of Drug Indications Us…

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Components

Assessing the effect of cimetidine treatment on tumor growth

Kandela, Aird, Iorns & 3 more
Replication attempt of Figure 4C-D and Supplement Figure 1 from Sirota et al., 2011.

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Meta-analyses


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Registered Report Additional Materials

Kandela, Zervantonakis, Iorns & 5 more

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Tags

cimetidinedrug retargetingmetasciencereplicationreproducibilityReproducibility Project: Cancer Biology

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