Development of QUADAS-C, a risk of bias tool for comparative diagnostic accuracy studies

  1. Sue Mallett
  2. Yemisi Takwoingi
  3. Clare Davenport
  4. Christopher Hyde
  5. Penny Whiting
  6. Mariska Leeflang

Date created: | Last Updated:


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Category: Project

Description: Comparative accuracy studies evaluate two or more index tests and compare their accuracy. Although these studies are susceptible to bias, their methodological quality is rarely assessed appropriately in systematic reviews. QUADAS-C was developed to help review authors to assess the risk of bias in comparative accuracy studies. It serves as an extension to the existing QUADAS-2 tool.


QUADAS-C is currently being prepared for publication. In 'Files' you can find the preliminary version of the tool, along with the guidance document.


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