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The goal of this project is to develop and disseminate an extension to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) for reviews of preclinical in vivo, animal experiment literature. This will be achieved through 1) an environmental scan of the characteristics and reporting quality of published preclinical systematic reviews; and 2) a Delphi exercise to determine consensus opinion on important items to be reported in such an extension.