Numerous major holidays celebrate socially gathering in person. However, in major holidays that happened during the pandemic, desires to nurture relationships and maintain holiday traditions often conflicted with physical distancing and other measures to protect against COVID-19. The current research sought to understand well-being during American Thanksgiving in 2020, which happened eight months into the COVID-19 pandemic, after months of physical distancing and stay-at-home orders. We asked 404 American adults how they spent Thanksgiving Day and to report on their experiences of that day. Predictors of well-being that we drew from self-determination theory were satisfaction of the fundamental needs for social connection (relatedness), for doing what one really wants (autonomy), and for feeling effective (competence). The predictors of well-being that we drew from regulatory focus theory were a focus on growth (promotion), and a focus on security (prevention). We found that feeling socially connected and focusing on growth related most strongly to well-being. Additionally, participants who saw even one other person face-to-face reported significantly higher relatedness satisfaction, promotion focus, and well-being than those who did not. Our research could help construct persuasive messages that encourage nurturing close relationships at major holidays while remaining safe against the virus.