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Description: ** If you would like to provide feedback on RAISE, please use this feedback form https://forms.office.com/e/EDYvBPEBrd ** The RAISE guidance is currently written in three documents (click 'Files' in the menu above). The first document, ‘RAISE 1’, provides tailored recommendations for eight of the distinct roles in the evidence synthesis ecosystem: evidence synthesists, methodologists, AI tool developments teams, organisations that produce evidence synthesis, publishers, funders, users, and trainers of evidence synthesis methods. RAISE 2 contains guidance on building and evaluating AI evidence synthesis tools, which focuses on determining if an AI tool does what it claims to do to an acceptable standard, including how to build and validate AI tools, conduct evaluations to build a cumulative evidence base, including performance metrics to consider, and report evaluations. The final document, RAISE 3, then offers guidance on selecting and using AI evidence synthesis tools, which focuses on understanding whether an AI tool can be used for a specific evidence synthesis, including how to assess, select and use an AI tool, including ethical, legal and regulatory considerations, and the current state of AI tools for evidence synthesis. Please see the storage area for the RAISE documents. https://osf.io/fwaud/files/osfstorage To cite RAISE, please use: Thomas J, Flemyng E, Noel-Storr, A. et al. Responsible AI in Evidence Synthesis (RAISE): guidance and recommendations (version 2; updated 3 June 2025). In: Open Science Framework [https://osf.io/], Washington DC: Center for Open Science. DOI 10.17605/OSF.IO/FWAUD (accessed XXX). We invite feedback and thoughts on this work. Please use https://forms.office.com/e/EDYvBPEBrd to submit feedback on RAISE.