The essay examines the relationship between the onomastics of anthroponyms in La Coscienza di Zeno and analyzes the profound meaning of the text. In particular, it will be shown that in the plot of the novel, the onomastics supported by textual clues and by a psychoanalytic interpretation, reveals through the investigation of the genotesto (Kristeva) the specularity between the ineptitude of the protagonist and the existential crisis of the man of Twentieth century.