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Description: Etiological models of alcohol and cannabis use disorders hypothesize that people are more likely to use and consume more of these substances when they experience heightened negative affect, yet recent EMA studies found no evidence for the daily association between negative affect and substance use. However, the theory underlying affect regulation of substance use is vague and has been translated into many different statistical tests across the literature, with inconsistent results. We aim to test the affect regulation hypothesis in a large sample of participants and across hundreds of statistical models to provide a robust understanding of whether and when affect regulation is supported in everyday life. This will enable us to update theoretical models and inform future clinical interventions aimed at the affect-substance use association.

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