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Functional magnetic resonance imaging (fMRI) has been particularly insightful about the underlying brain systems engaged in the experience of pain. It holds great potential as a tool for investigating the mechanisms of pharmacological and non-pharmacological pain therapies. However, to maximise confidence in fMRI results, it is important to examine the ability of fMRI paradigms to generate a stable and reliable signal relative to the perception of pain. Therefore, the main objective of the present study is to determine the reliability of brain and spinal blood oxygen level dependent (BOLD) fMRI signals during evoked responses to noxious stimulation and guided motor activity, as well as the reliability of resting-state fMRI. This study will comprise three sessions, including a set-up/screening session (during which participant eligibility will be assessed and their pain responses tested) and two fMRI sessions. During the fMRI sessions, participants will undergo a resting-state paradigm, two runs of a pressure pain stimulation paradigm (left and right hand, order counterbalanced), and a guided motor paradigm.
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