Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all data, analysis scripts, and methods for the replication of the experiment reported in Figure 4C and Supplemental Figure 1 of [Sirota et al., 2011][3]. This experiment assesses the effect of cimetidine treatment on tumor growth. <br> ### Contents [Figures component][4] contains a visualization of replication results. These figures are the same as can be found in the Replication Study and include Figure 1 displaying tumor volumes and Figure 2 displaying tumor weights. [Statistical Analyses component][5] contains R scripts that were used for the analysis. [Data component][6] contains data generated from the experimental work and files used in the analysis and generation of figures, which are in .csv format. [Methods component][7] contains additional methodology details for this replication attempt which were described in the [Registered Report][8]. [Cell line quality control data][9] includes results confirming the cell lines were free of mycoplasma contamination and common mouse pathogens as well as STR DNA profiling of the cell lines used. [1]: https://osf.io/yc8k2/ [2]: http://elifesciences.org/content/4/e06959v1 [3]: http://stm.sciencemag.org/content/3/96/96ra77 [4]: https://osf.io/f4pk5/wiki/home/ [5]: https://osf.io/kyftg/wiki/home/ [6]: https://osf.io/xcuh6/wiki/home/ [7]: https://osf.io/vfp24/wiki/home/ [8]: http://elifesciences.org/content/4/e06959v1 [9]: https://osf.io/yt9fv/wiki/home/