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This panel contains an overview of the project and a running update of changes that have been made. Please click "read more" to see the entire overview. --------------- **UPDATE 7/8/22** --------------- - We updated the instructions for reviewers to reflect changes in the way the species of the cell or cellular component is coded for in vitro studies. - We added a [codebook][1] to the Data Output component that further describes the data structure and provides additional explanation for column headers within the data for included studies. - We deleted old versions of data files so that only final versions are viewable here. (Note that old versions of files can be found in the multiple project registrations). --------------- **UPDATE 5/11/22** --------------- We updated the data in the database based on feedback from peer-reviewers of our manuscript submitted to Environment International. Details of the updates can be found in our Project under "[Data from Included Studies][2]." We updated the display of the database in Tableau. - The "Cell Species" header for *in vitro* studies was changed to "Cell or Cell Component Species" - A broken filter for the "Cell or Cell Component Species" was fixed. --------------- **UPDATE 4/29/22** --------------- We updated the display of the database in Tableau. - The "potential COI" filter was not properly working. This was corrected. - Additional instructions for resetting the filters was added to the "How To Use" on screen-instrucitions. - The data label "Exposure Range" was changed to "Exposure Values" in the tool tip hover-over for selected studies. --------------- **UPDATE 11/9/21** --------------- We released an update to the PFAS-Tox Database on November 9, 2021, now incorporating data from the January 25, 2021 PubMed literature search. ------------------ **UPDATE 4/20/21** ------------------ You can now view the output of this project at [PFASToxDatabase.org][3] Please cite the PFAS-Tox Database as: Pelch KE, Reade A, Kwiatkowski CF, Wolffe T, Merced-Nieves FM, Cavalier H, Schultz K, Rose K, Varshavsky J. 2021. PFAS-Tox Database available at https://pfastoxdatabase.org DOI: 10.17605/OSF.IO/F9UPX ---------- **Background:** --------------- Per- and polyfluoroalkyl substances (PFAS) confer waterproof, greaseproof, and non-stick properties when added to consumer products. They are also used for industrial purposes including in aqueous film forming foams for firefighting. PFAS are ubiquitous in the environment, are widely detected in human biomonitoring studies, and are of growing regulatory concern across federal, state, and local governments. Regulators, scientists, and citizens need to stay informed on the growing health and toxicology literature related to PFAS. **Objectives:** --------------- The goal of this systematic evidence map is to identify and organize the available health and toxicology related literature on a set of 29 PFAS of emerging and growing concern. **Search and study eligibility:** --------------------------------- We will search the electronic database PubMed for health or toxicological studies on 29 PFAS of emerging concern. Eligible studies must contain primary research investigating the link between one or more of the PFAS of interest and a health effect, toxicological, or biological mechanistic endpoint. **Study appraisal and synthesis methods:** ------------------------------------------ Title and abstract screening and full text review will require a single reviewer for inclusion to the next level and two independent reviewers for exclusion. Study quality will not be conducted for this evidence mapping. Study characteristics will be extracted and coded from the included studies and checked for accuracy by a second reviewer. The extracted and coded information will be visualized in a publicly available, interactive database hosted on Tableau Public. Results of the evidence mapping will be published in a narrative summary. [1]: https://osf.io/4yct7 [2]: https://osf.io/cwk87/ [3]: https://pfastoxdatabase.org