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The Reproducibility Project: Cancer Biology is a collaboration between Science Exchange and the Center for Open Science, and is independently replicating a subset of experimental results from a number of high-profile papers in the field of cancer biology studies published between 2010-2012 using the Science Exchange network of expert scientific labs.


What are the aims of the project?

Through independent direct replication studies, the project aims to identify best practices that maximize reproducibility and facilitate an accurate accumulation of knowledge, enabling potentially impactful novel findings to be effectively built upon by the scientific community.

Additionally we expect to learn about:

  • The overall rate of reproducibility in a sample of the published cancer biology literature.
  • Obstacles that arise in conducting direct replications of original studies.
  • The feasibility and practical challenges of getting proper materials, methods, and instrumentation for a replication.
  • Predictors of replication success such as the journal in which the original finding was published, the citation impact of the original report, the number of direct replications that have been published elsewhere, the transparency of materials and methods included with the publication, and adherence to publishing checklists and guidelines.

For additional information read the feature article published by eLife that introduces and summarizes the project.

Who is involved in the project?

The Reproducibility Project: Cancer Biology is managed by a core team of personnel who develops and executes the project design. These individuals coordinate and participate in coding information from the original papers while also maintaining communication with the original authors and Science Exchange provider labs who perform the replication experiments. A biography of each of the core team members can be viewed on the Core Project Team page.

The Reproducibility Project: Cancer Biology is also advised by leaders on the issue of reproducibility. For a list and a short biography of the advisors, visit the Advisory Board page.

Additionally, funding and supporting organization for this project can be seen by visiting the Funding and Supporting Organizations page.

Which studies are being replicated?

For the methodology of what studies were eligible for inclusion and for the list of the 50 cancer biology studies to be replicated, visit the Studies page. The results of the individual replication projects can be viewed under the Replication Studies component.

View the Project Progress spreadsheet to see the current overall progress.

Where can I find the results?

This project is being organized on the Open Science Framework (OSF). The OSF is a free service and is where all the experimental protocols, materials, data, analysis, and results will made openly available to the public. The information on the project can be accessed from the column to the left and the navigation bar at the top.

Furthermore, quality assurance will be maintained with the Registered Reports format, in which peer review of proposed experimental designs and protocols will be conducted prior to data collection, in conjunction with eLife with the eventual results published in a Replication Study.

All published articles related to the project can be found on the Reproducibility Project: Cancer Biology collection at eLife.

For more information:

See the executive summary or visit the Studies, Core Project Team, Advisory Board, Press, Funding and Supporting Organizations, or FAQ page.

Questions or are interest in supporting the project can be directed to contact@cos.io.

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