The Reproducibility Project: Cancer Biology is a collaboration between Science Exchange and the Center for Open Science, and is independently replicating a subset of experimental results from 50 high-impact cancer biology studies published between 2010-2012 using the Science Exchange network of expert scientific labs.
Science Exchange is a marketplace for scientific collaboration, where researchers can order experiments from the world's best labs.
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The Center for Open Science (COS) is dedicated to improving the alignment between scientific values and scientific practices to improve the accumulation and application of knowledge.
What are the aims of the project?
Through independent direct replication studies, the project aims to identify best practices that maximize reproducibility and facilitate an accurate accumulation of knowledge, enabling potentially impactful novel findings to be effectively built upon by the scientific community.
Additionally we expect to learn about:
For additional information read the feature article published by eLife that introduces and summarizes the project.
Who is involved in the project?
The Reproducibility Project: Cancer Biology is managed by a core team of personnel who develops and executes the project design. These individuals coordinate and participate in coding information from the original papers while also maintaining communication with the original authors and Science Exchange provider labs who perform the replication experiments. A biography of each of the core team members can be viewed on the Core Project Team page.
The Reproducibility Project: Cancer Biology is also advised by leaders on the issue of reproducibility. For a list and a short biography of the advisors, visit the Advisory Board page.
Additionally, funding and supporting organization for this project can be seen by visiting the Funding and Supporting Organizations page.
Which studies are being replicated?
For the methodology of what studies were eligible for inclusion and for the list of the 50 cancer biology studies to be replicated, visit the Studies page. The results of the individual replication projects can be viewed under the Replication Studies component.
spreadsheet to see the current overall progress.
Where can I find the results?
This project is being organized on the Open Science Framework (OSF). The OSF is a free service and is where all the experimental protocols, materials, data, analysis, and results will made openly available to the public. The information on the project can be accessed from the column to the left and the navigation bar at the top.
Furthermore, quality assurance will be maintained with the Registered Reports format, in which peer review of proposed experimental designs and protocols will be conducted prior to data collection, in conjunction with eLife with the eventual results published in a Replication Study.
All published articles related to the project can be found on the Reproducibility Project: Cancer Biology collection by eLife.
For more information:
If you have any questions please contact the RP:CB core team at email@example.com.