This scoping review aims to identify and map the scope of current published literature of physiological stress responses to high acuity scenarios and, importantly, identify and analyse knowledge gaps 32. To achieve the aim, the following search strategy was employed: • Participants: higher education students or students in non-university training programs studying towards a recognised health care qualification. • Concept: any study that incorporates clinical scenarios / simulations where physiological (cardiovascular or endocrine) /or psychophysiological data is recorded. • Context: any undergraduate or postgraduate higher education setting or equivalent non-university training facility for the participants mentioned above. Search Strategy To ensure this review examined the acute physiological stress response, it was necessary to focus on articles that assessed markers of stress in real-time as participants were exposed to a stress-inducing task. To achieve this, mobile wearable technology was a key requirement for data acquisition in the studies reviewed. First envisaged by Parkinson’s disease researchers in the early 1990’s as a means of field monitoring patients outside of care facilities, it was not until late in the century that technology allowed clinical application and only in the 21st century when such wearable technology has become a mainstay in most people’s lives. Therefore, as part of this scoping review a date restriction of articles from 2000 onwards has been applied reflecting technological advancements in the field of passive real-time stress monitoring. In 2013, a methodological working group from JBI developed a detailed and comprehensive guide for authors to use when conducting scoping reviews. Continually updated, the latest version (released in 2020) has been followed step-by-step within this review. An initial search was conducted across three prominent databases (Medline, PubMed and Scopus) to determine key terms as a guide to developing a thorough search strategy. From this, the secondary search expanded all identified keywords and incorporated medical subject headings (MeSh), major subject areas, and all other possible index terms as noted in the Appendix 1. The strategy considered paramedic-specific search filters, as defined recently by Olaussen, Semple , but expanded beyond these with the aim of capturing studies of any health care education or training. The protocol incorporated both published (peer-reviewed academic papers, reports and conference proceedings) and unpublished (grey literature) evidence, but did exclude non-English language articles. Sources were gathered using EBSCOhost (including Medline, CINAHL and APA PsycInfo) Scopus, PubMed, and Google Scholar. Other articles that cited the retrieved articles were also checked using citation alert with the ISI Web of Knowledge