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Patterns of neural activity and reduced responses to threatening faces are predictive of autistic traits: modulatory effects of alexithymia and oxytocin receptor genotype
- Xiaoxiao Zheng
- Feng Zhou
- Meina Fu
- Lei Xu
- Jialin Li
- Keshuang Li
- Benjamin Becker
- Yang Zhan
- Keith Kendrick
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Description: Autistic individuals generally demonstrate impaired emotion recognition but it is still unclear whether effects are emotion-specific. There is also evidence that co-morbid alexithymia or oxytocin receptor (OXTR) genotype might influence altered emotion recognition in autism. Against this background we implemented a dimensional approach using an implicit emotion recognition task together with functional MRI and genetics in a large cohort of subjects (N=255) to establish associations between autistic traits and neural and behavioral responses to specific face emotions, together with modulatory effects of alexithymia and OXTR genotype.
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