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Description: Connective tissue cells, including fibroblasts, cartilage and bone cells, are specialized in the secretion of fibrillar proteins (primarily collagens), which are used for building intercellular substance. The intercellular matrix is a complex substance found in the interstitial intracellular space (between cells). In connective, cartilage and bone tissue, the intercellular matrix occupies a significant volume and performs its main functions. Bone formation Cells of mesenchymal origin - fibroblasts, osteoblasts - synthesize and secrete collagen fibrils, which are in the matrix containing also proteoglycans and glycosaminoglycans. Mineral components come from the surrounding liquid phase, crystal lattice formation is induced by nucleation (three-chain collagen activates crystal formation).