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This wiki outlines the different components of the fluency LSM project and is divided into the following sections: 1. **[Lesion Segmentation][1]** - information about how automated lesion segmentation and reproducible quality assurance were performed 2. **[LSM Analyses][2]** - details how the mass-univariate and multivariate lesion symptom mapping analyses were run 3. **[Results][3]** - an overview of the results of each LSM analysis Additional information about the participants used in the present study is presented below. All wiki pages provide links to the relevant data, scripts, and figures. ---------- **Participants** Participants were taken from two longitudinal studies investigating recovery after stroke. The first, **the Constraint Induced Aphasia Therapy Study (CIAT)**, took place from approximately 2008 to 2014. Participants were recruited immediately after stroke and followed for a year. Psycholinguistic and MRI data from a single testing session conducted at 6 or 12 months were used in this study. Previous studies have described the study design and longitudinal recovery of these patients ([Griffis, Nenert, Allendorfer, & Szaflarski, 2017][4]; [Nenert et al., 2018][5]; [Szaflarski et al., 2015][6]). The second longitudinal study, **the Post-Stroke Aphasia & rTMS Treatment Study (PART)**, was run from 2012 to 2016. Participants with chronic aphasia (> 1 year post-stroke) were recruited to a treatment trial study examining the efficacy of repetitive transcranial magnetic stimulation (rTMS) in recovery. Psycholinguistic and MRI data from the first testing session were used in this study. Previous studies have described the study design and efficacy of the rTMS treatment ([Allendorfer, Storrs, & Szaflarski, 2012][7]; [Griffis, Nenert, Allendorfer, & Szaflarski, 2016][8]; [Shah, Szaflarski, Allendorfer, & Hamilton, 2013][9]). Participant demographic information is available in this [**table**][10]. [1]: https://osf.io/crv4f/wiki/Lesion%20Segmentation/?edit&view&menu [2]: https://osf.io/crv4f/wiki/LSM%20Analyses/ [3]: https://osf.io/crv4f/wiki/Results/?edit&view&menu [4]: https://www.ncbi.nlm.nih.gov/pubmed/28337410 [5]: https://www.ncbi.nlm.nih.gov/pubmed/29782329 [6]: https://www.ncbi.nlm.nih.gov/pubmed/26399192 [7]: https://www.ncbi.nlm.nih.gov/pubmed/22233802 [8]: https://www.ncbi.nlm.nih.gov/pubmed/26881111 [9]: https://www.ncbi.nlm.nih.gov/pubmed/24399952 [10]: https://osf.io/mg8kf/
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