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Extreme Open Science: Companies Sharing Compounds without Restriction
- David Drewry
- Carrow Wells
- William J Zuercher
- Timothy M Willson
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Category: Project
Description: Although the human genome provides the blueprint for life, most of the proteins it encodes remain poorly studied. We describe how one group of scientists, in seeking new targets for drug discovery, used open science through unrestricted sharing of small molecules to shed light on dark matter of the genome. Starting initially with a single pharmaceutical company before expanding to multiple companies, a precedent was established for sharing published kinase inhibitors as chemical tools. As a result, new drug targets were identified and the science of kinase chemogenomics was established.