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Description: PUBLISHED STUDY. Recent findings demonstrated readers’ sensitivity to the distinction between consonant and vowel (CV) letters. Especially, the way consonants and vowels are organised within written words determines their perceptual structure. One consequence of these results is the need to revise current models of visual word recognition. Before tackling such a challenge, two further assumptions need to be tested, namely, first, that effects of CV structure occur at an early stage during letter string processing, and second, that the CV pattern determines the units at one level in the hierarchy of neural detectors coding orthography. The aim of the paper is to directly test these two claims using MEG recording while participants perform a same-different matching task.