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**Performing Actions in a Changing Environment** (**PACE**) Catching a falling cellphone and reaching a fast approaching tennis ball even when those are temporarily precluded by visual obstacles are examples of remarkable predictive interceptive actions that humans can normally perform. This ability requires dynamic visual motion processing and fine predictive motor control that rely on manifold information, principally processed in the medial parieto-frontal network, a circuit linking in humans and non-human primates the medial posterior parietal cortex (*PPC*), the dorsal premotor cortex (*PMd*), and the prefrontal cortex through direct cortico-cortical connections and, subcortically, via the striatum. In primates, the medial *PPC* is essential for the sensorimotor transformations required for planning and executing hand movements towards external stimuli. The medial *PPC* receives signals from nearby visual motion areas, which suggests an essential contribution by the medial parieto-frontal network to the predictive processing of motor control in dynamic conditions. Thus, PACE will investigate the structure of the cortical and subcortical networks supporting visually guided sensorimotor control of reaching and provide a neurocomputational mechanism. The team: 1. Patrizia Fattori, [Università degli Studi di BOLOGNA][1], PI and Coordinator of electrophysiology, neuroanatomy, and kinematic unit 2. Borra Elena, Università degli Studi di PARMA, Coordinator of neuroanatomy unit 3. Bosco Gianfranco, Università degli Studi di ROMA "Tor Vergata", Coordinator of TMS and behavior unit 4. Genovesio Aldo, Università degli Studi di ROMA "La Sapienza", Coordinator of electrophysiology unit 5. Stoianov Ivilin Peev, [Consiglio Nazionale delle Ricerche][2], Coordinator of neurocomputational modelling unit [1]: http://www.gallettilab.unibo.it/index.htm [2]: https://www.istc.cnr.it/en/people/ivilin-peev-stoianov
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