This project contains all information pertaining to the replication of experiments from “Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF” published in *Cell* in 2010 ([Heidorn et al., 2010][1]). Experimental work began although not all experiments were completed. The completed experiments were included in the summary paper "Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology" ([Errington et al., 2021][2]). <br> Also, explore the Registered Report and materials related to the Registered Report [here][3]. <br> **Data and Material Availability**: All other associated data, protocols, analysis scripts, and other digital materials are available within this OSF project. **Experiments replicated**: Reproduce and explore the figures, analyses, data, and methods generated in this replication attempt. - [Treatment of BRAF mutant cells with various RAF inhibitors and assessment of activation of ERK][4] - Replication of Figures 1A of Heidorn et al., 2010 - [Preliminary results of other experiments described in the Registered Report][5] - Attempt of replication of 1B, 3A, 3B, and 4D of Heidorn et al., 2010 <br> Questions about the project can be directed to contact+rpcb@cos.io. [1]: https://doi.org/10.1016/j.cell.2009.12.040 [2]: https://doi.org/10.7554/eLife.73430 [3]: https://elifesciences.org/articles/11999 [4]: https://osf.io/a3bre/wiki/home [5]: https://osf.io/w2rva/wiki/home