**Open science research project** The most recent research projects in scientific field of eutherian comparative genomics included intentions to sequence every extant eutherian species genome in foreseeable future, so that future revisions and updates of eutherian gene data sets were expected. Importantly, the human protein coding gene census remained unfinished: contemporary estimates included **≈ 20000-21000** protein coding genes in human genome, in contrast to human initial integrated gene index that included **≈ 32000** known and predicted protein coding genes. The research project entitled "**Comparative genomic analysis of eutherian genes**" conformed to open science hallmarks. First, the project used public eutherian reference genomic sequence data sets, including **human and 34 other placental mammals**. Using free available computer programs, the project established **eutherian comparative genomic analysis protocol RRID:SCR_014401** as one framework of eutherian gene revisions that was applicable in curation of **14 gene data sets** implicated in major physiological and pathological processes. In aggregate, the omnibus research project made available in public biological databases **2615 eutherian complete coding sequences**. **Author:** Marko Premzl PhD, The Australian National University Alumni (WFH) **E-mail contact:** Marko.Premzl@alumni.anu.edu.au **PROJECT IN BRIEF** **Duration:** 2009 - present **Equipment:** 1 PC with internet connectivity **Funding:** Author **Gene data sets:** 14 **Complete coding sequences:** 2615 **Publications:** 18 **Peer-reviewed publications:** 16