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Protocol For Scoping Review On Efficacy And Safety Of Targeted Therapy And Immunotherapy in Advanced Vulvar Squamous Cell Carcinoma (RENOUNCE)
- Martina Parenza Arenhardt
- Jessé Lopes da Silva
- Giovanna Vieira Giannecchini
- Diocesio Alves Pinto de Andrade
- Larissa Müller Gomes
- Marcela Bonalumi dos Santos
- Andréia Cristina de Melo
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Description: Vulvar carcinoma comprises approximately 4% of gynecological cancers, with vulvar squamous cell carcinomas (VSCC) representing 80% of cases. The main risk factor for the development of the disease is HPV infection. The VSCC prognosis is linked to staging at diagnosis. In the metastatic setting, options for treatment are limited. Chemotherapy protocols are frequently adapted from data on cervical cancer, with surgery and radiotherapy serving as additional therapeutic modalities. The aim of this scoping review is to evaluate the efficacy and safety of immunotherapy and targeted therapy in women with advanced vulvar cancer using a systematic literature search strategy.
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