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MTOR-dependent stimulation of IL20RA orchestrates immune cell trafficking through lymphatic endothelium in patients with Crohn’s disease
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Crohn’s disease (CD) is a chronic inflammatory condition that can affect different portions of the gastrointestinal tract. Lymphatic drainage was demonstrated to be dysfunctional in CD pathogenesis, ultimately causing the failure of the resolution of intestinal inflammation. To investigate the molecular mechanisms underlying these dysfunctions, we isolated human intestinal lymphatic endothelial ce…
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