On January 6-8th, 2021, bioinformatics researchers from around the world came together virtually to collaboratively develop a framework for clinical reporting of RNA-Seq research. For the second year in a row, CMU Libraries was thrilled to provide support for a clinical genomics hackathon! This support included finding and organizing references, helping organize, review, and clean up the manuscript resulting from the hackathon, and giving feedback on READMEs and reproducibility. In the Components of this project, you can find direct links to the work of each of the four teams. These distinct teams worked collaboratively and iteratively with the same dataset to provide a framework for clinical reporting of RNA-Seq research.