Associations between an IgG3 polymorphism in the binding domain to FcRn transplacental transfer of malaria-specific IgG3 and protection against Plasmodium falciparum malaria during infancy


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Description: A mutation of IgG3-R435H that enhances binding to FcRn results in increased transplacental transfer of maternal malaria-specific IgG3, extended IgG3 half-life in the neonate and reduced risk of Plasmodium falciparum infection and disease in infancy.


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