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Description: Depression is characterized by affective symptoms and neuropsychological deficits. After treatment, affective symptoms frequently remit, but cognitive alterations may remain affecting the lives of people and having an impact on health, economy, and societies. The present work describes the methods, procedures, and equipment of a randomized three-arm controlled experiment designed to measure the effects of exergames on executive functions (EFs) under depression. EFs are complex functions that are essential for organizing information, planning an action, reasoning, decision-making, and problem-solving. Literature shows that EFs are compromised under depression, affecting daily-life activities and other cognitive domains. To conduct the experiment, middle-aged adults with depression will be randomly distributed into three experimental groups: an intervention group training with exergames, an active control group training only with cognitive video games, and a passive control group or wait list. EFs are evaluated at three different time points: before the cognitive-behavioral intervention, after the intervention, and three months follow-up, using the Wisconsin Card Sorting Test (WCST). Researchers will collect cognitive-behavioral and neural information (event-related potentials, ERPs). Results will be explored….continue reading Preprint: https://doi.org/10.31234/osf.io/m7s2t...acess to the published protocol: https://doi.org/10.37349/en.2024.00068 UPDATE 23/12/2024: The latest version of the Preprint1 work (peer-review) is published with the DOI: https://doi.org/10.37349/en.2024.00068 (The article is Open Access and everyone can read and download it for free) Journal: Exploration of Neuroscience (indexed by DOAJ, the Directory of open access journals, an index of high-quality, open-access, peer-review journals). Received: October 14, 2024 Accepted: December 12, 2024 Published: December 23, 2024 RELATED PROJECTS AND PUBLICATIONS: 1. Preprint1: Protocol for measuring the benefits of exergames on executive functions under depression through a randomized multi-arm controlled experiment https://doi.org/10.31234/osf.io/m7s2t 2. Preprint2: Neurophysiology Of Executive Cognitive Functions Under Depression: A Theoretical Review. https://doi.org/10.31219/osf.io/f5dhq 4. Project1: MUDgame. Measuring the Benefits of an Exergame-based intervention on Neuro-Cognitive Functions in adults suffering from Depression. A Randomized Multi-Arm Controlled Experiment. https://doi.org/10.17605/OSF.IO/YBDCT 3. Project2: Neurophysiology of Executive Cognitive Functions under Depression: A Theoretical Review. https://doi.org/10.17605/OSF.IO/RQ357 5. Clinical Trial Registration: Benefits of Exergames on Neurocognitive Functions in Adults Suffering from Depression.MUDGAME Study Registration Clinical Trial. A Randomized Controlled Experiment (ClinicalTrials.gov ID: NCT06536530) https://clinicaltrials.gov/study/NCT06536530 6. Project Preregistration OSF Registries: MUDgame. Measuring the Benefits of an Exergame-based intervention on Neuro-Cognitive Functions in adults suffering from Depression. A Randomized Multi-Arm Controlled Experiment. https://osf.io/z4s9q