The graded calorie restriction project

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Contributors:
  5. Alex Douglas
  8. Yingchun Wang
  9. Jing Dong Jackie Han
  10. Luonan Chen
  11. Lu Wang
  13. Luigi Fontana

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Description: The aim of this project is to expose mice to graded levels of calorie restriction to find responses that correlate to the graded nature of the restriction

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Background and rationale Calorie restriction (eating fewer calories than the daily metabolic requirement) has been known for almost 100 years to result in extension of life and a reduction in the rate of ageing/age related disease prevalence (reviewed in Speakman and Mitchell 2011: see uploaded pdf). It is effective in a wide range of organisms from yeast and C.elegans, to spiders, Drosophila, rod...

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