The graded calorie restriction project

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Description: The aim of this project is to expose mice to graded levels of calorie restriction to find responses that correlate to the graded nature of the restriction


Background and rationale Calorie restriction (eating fewer calories than the daily metabolic requirement) has been known for almost 100 years to result in extension of life and a reduction in the rate of ageing/age related disease prevalence (reviewed in Speakman and Mitchell 2011: see uploaded pdf). It is effective in a wide range of organisms from yeast and C.elegans, to spiders, Drosophila, rod...


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