The CRACKIT Virtual Infectious Disease project, funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) represents a series of investigations into the host response during experimental visceral leishmaniasis with the aim of generating an in silico virtual laboratory that will inform drug and vaccine development. Individual aspects of the CRACKIT program are being published separately and underlying data will be held on this site. The leishmaniasis virtual laboratory (LeishSim) can be explored at www.leishsim.org. Associted histopathology data can be viewed at www.leishpathnet.com.
Ashwin et al describes the transcriptomic response of BALB/c mice to L. donovani infection, analysing multiple time poits and multiple tissue sites. Raw data fr Figures 1 and 6 are provided here along with Supplementary Tables containing the DE gene lists derived from https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113376.
Forrester et al decribes the transcriptomic response at one and seven days after treatment with AmBisome (8mg/kg) in both spleen and liver. Raw data are provided for Figure 1A and B,Figure 4 and Figure 5A and B, along with supplementary Tables derived from https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113376 and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138825 and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE140799
