Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies

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Description: We employed a coordinate-based meta-analysis for task-based neuroimaging literature using activation likelihood estimation (ALE), whereby, coordinates were extracted from clusters with significant differences in intranasal oxytocin versus placebo in healthy adults. Data were included for 39 fMRI studies that reported a total of 372 distinct foci in 1568 participants. We also performed an effect-size meta-analysis on reported t-statistics to test for publication bias.

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This systematic review has been pre-registered on PROSPERO. Uncorrected statistical maps from the ALE meta-analysis are available on NeuroVault: https://neurovault.org/collections/3713/

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