Chronic inflammation has been linked to a myriad of negative health outcomes like cancer and Alzheimer’s disease (Redwine et. al, 2016). Researchers are working to identify inexpensive ways to buffer against stressors that lead to inflammation. One such buffer is gratitude (Mills et al., 2015). A grateful disposition, or the tendency to respond to life events with grateful emotion, is linked to positive affective traits and decreased inflammation (McCullough et al., 2002). Few studies, however, have examined the relationship between gratitude and inflammation in adolescents. As part of the Study of Family Health, 160 adolescents completed the Gratitude Questionnaire-Six-Item Form and provided blood samples to measure C-reactive protein, a biomarker of inflammation. We hypothesize that adolescents with higher levels of gratitude will have lower inflammation. Individual differences in socioeconomic status (SES) will be examined for potential moderating effects, as a follow-up to Hartanto et. al’s (2019) finding that gratitude moderates the link between SES and inflammation. These findings may shed light on a practice that could have a positive impact on adolescent physical health.