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Figure 4. Efficacy study of I-BET151 in xenograft mouse model of MLL-fusion leukaemia. Female NOD-SCID mice were xenotransplanted with 1x107 MV4;11 cells after conditioning with Busulfan. Following establishment of disease (detectable MV4;11 cells from retro-orbital bleeds), mice were randomly assigned to receive daily IP injections of 20 mg/kg I-BET151 or vehicle control. (A) Kaplan-Meier plot of...

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