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The overall objective of the research project is to systematically map when and how acceptable daily intake (ADI) values are used as health-based benchmarks in nutrition research studies that consider the safety of low-calorie sweeteners (LCS) as it relates to measured or estimated consumption. In this mapping exercise, there are no explicit outcomes or interventions. Rather, the concept under evaluation - safe consumption levels of LCS as defined by ADI values established by authoritative bodies – implicitly contains outcomes related to safety. ADI values are unique to individual LCS, each of which is established by comprehensively reviewing toxicological data and following specific processes to conservatively establish ADI values. Results will be synthesized and integrated relative to the definition, development, and use of ADI values for LCS by authoritative bodies, such as the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the U.S. Food and Drug Administration (FDA) or the European Food Safety Authority (EFSA).
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