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Description: Diffuse alveolar damage (DAD) is a common histopathological finding associated with severe viral infections, including SARS-CoV-2. However, the mechanisms mediating progression of DAD are poorly understood. Applying protein digital spatial profiling to lung tissue obtained from a cohort of 27 COVID-19 autopsy cases from the UK, we identified a protein signature (ARG1, CD127, GZMB, IDO1, Ki67, phospho-PRAS40 (T246) and VISTA) that distinguishes early / exudative DAD from late / organising DAD with good predictive accuracy. These proteins warrant further investigation as potential immunotherapeutic targets to modulate DAD progression and improve patient outcome. This project contains raw protein expression data from the digital spatial profiling study reported in "Identification of a protein expression signature distinguishing early from organising diffuse alveolar damage in COVID-19 patients." by Ashwin et al