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Are cognitive deficits associated with tobacco abstinence mediated by dopamine depletion?
- Meryem Grabski
- Angela Attwood
- Olivia Abrams
- Val Curran
- David Nutt
- Stephen Husbands
- Stuart Ferguson
- Tim Williams
- Marcus Munafo
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Category: Project
Description: This study aims to investigate the dose-dependent effects of apomorphine (a dopaminergic agonist) on cognition and craving in acutely abstinent smokers. This is a within-subjects, double-blinded experimental study in which apomorphine and placebo nasal sprays will be administered in a counterbalanced order. Dependent variables include cognitive task performance and tobacco craving levels (measured using ecological momentary assessment).