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Choline Supplementation Attenuates Experimental Sepsis-Associated Acute Kidney Injury

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Description: Plasma and urine NMR-base metabolomics in both a mouse model of SA-AKI and human pediatric SA-AKI indicate that choline and central carbon metabolism are integral to the SA-AKI pathophysiology. In our mouse model, treatment with intraperitoneal choline improved renal function and trended towards decreased AKI incidence.

License: CC-By Attribution 4.0 International

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