The inaugural [Open Science Symposium][1] (OSS) was held on October 18 and 19th, 2018 at the Mellon Institute of Carnegie Mellon University. The OSS brought together students and researchers from a wide variety of departments at Carnegie Mellon University (CMU) and University of Pittsburgh to discuss open science. The first day, October 18th, was a series of panel discussions from researchers, publishers, and developers that are working on innovative open science practices and tools, both at CMU and other institutions. A Scientific Speed Dating event encouraged researchers from different disciplines to informally discuss their work and look for collaboration opportunities. The second day, October 19th, was a series of hands-on workshops on popular and reliable tools and platforms for practicing open science. The Open Science Symposium was a joint event by Mellon College of Science and University Libraries, supported by funding from the DSF Charitable Foundation. It was organized by Melanie Gainey, Ana Van Gulick, and Huajin Wang of University Libraries and Eric Yttri, assistant professor of Biological Sciences and Center for Neural Basis of Cognition (CNBC). [1]: https://events.mcs.cmu.edu/oss2018/