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<p>This component includes data and analysis scripts for the meta-analyses of the effects from the experiment reported in Figures 2A-C of <a href="http://www.cell.com/cancer-cell/abstract/S1535-6108%2810%2900036-X" rel="nofollow">Ward et al., 2010</a> and the replication of this experiment.</p> <p><strong>Figure 4. Meta-analyses of each effect.</strong> Effect size and 95% confidence interval are presented for Ward et al., 2010, this replication study (RP:CB), and a random effects meta-analysis of those two effects. Sample sizes used in Ward et al., 2010 and this replication attempt are reported under the study name. Random effects meta-analysis of AML patient samples with an IDH1 mutation compared to a constant of 0.01 (1% 2HG/glutamate level) (meta-analysis p = .214), AML patient samples with an IDH2 mutation compared to a constant of 0.01 (meta-analysis p = .011), and AML patient samples with an IDH1 or IDH2 mutation compared to a constant of 0.01 (meta-analysis p = .012). Additional details for these meta-analyses can be found at <a href="https://osf.io/4m3n8/" rel="nofollow">https://osf.io/4m3n8/</a>.</p> <p>Access <a href="https://osf.io/pdsr9/" rel="nofollow">full size image</a> and <a href="https://osf.io/t5gf9/files/" rel="nofollow">R script</a> used to generate this figure. These scripts will call the <a href="https://osf.io/atnbu/" rel="nofollow">data</a> directly from the OSF.</p> <p>Access <a href="https://osf.io/jg4cu/" rel="nofollow">analysis script</a>. </p>
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