Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all primary data, analysis scripts, and QC data for the replication of the experiment reported in Figure S6A of [Berger et al. 2012][3]. This experiment was performed to assess the protein expression of PREX2 in NRAS^G12D melanocytes which stably expressed GFP, PREX2^WT, PREX2^G844D, or PREX2^Q1430*. Endogenous PREX2 was probed as well as the exogenously expressed variants. PREX2 expression was compared between cells generated by the original lab and this replication attempt. ## Contents [Figures component][4] contains a visualization of the replication results. These figures are the same as can be found in the Replication Study and include Figure 2 displaying the Western blot results. [Statistical Analyses component][5] contains R scripts that were used for the analyses. [Data Component][6], contains data generated from the experimental work and files used in the analysis and generation of figures, which are in .csv format. [Methods component][7] contains methodology details for this replication attempt which were described in the [Registered Report][8]. [Plasmid quality control data][9] includes the sequencing results from the plasmids used to generate the stable cell lines is available. [Cell line quality control data][10] includes results confirming the cell lines were free of mycoplasma contamination as well as STR DNA profiling of the cell lines used. [1]: https://osf.io/rvyg5/ [2]: https://elifesciences.org/content/3/e04180 [3]: http://www.nature.com/nature/journal/v485/n7399/full/nature11071.html [4]: https://osf.io/me37j/wiki/home/ [5]: https://osf.io/w52c7/wiki/home [6]: https://osf.io/nm2jv/wiki/home/ [7]: https://osf.io/evf2d/wiki/home/ [8]: https://elifesciences.org/content/3/e04180 [9]: https://osf.io/dhch3/wiki/home/ [10]: https://osf.io/38wq2/wiki/home/