The outcomes disparity between LGBT+ and cis-heterosexual students has led to the growth of campus climate research in the USA. A mixed-method, cross-cultural comparative campus climate study sampled from a highly conservative setting (Philippines; Pew Research Center, 2013) and a more progressive setting (UK; ILGA-Europe, 2018) was conducted to examine the current levels of traditional and modern anti-LGBT+ prejudice in higher education (HE) and to provide a holistic and intersectional picture of the current campus climate for LGBT+ students. Results of quantitative cross-cultural comparisons among LGBT+ students' (N = 469 [UK], 408 [PH]) and cis-heterosexual students' (N = 960 [UK], 1,147 [PH]) campus climate perceptions, experiences of harassment, levels of anti-LGBT+ prejudice, and well-being reveal that modern anti-LGBT+ prejudice still pervades HE, leading to more negative campus climate outcomes for LGBT+ students in UK and Philippine HEIs. Thematic analysis of focus groups and interviews with LGBT+ students (N = 18 [UK], 18 [PH]) echo the prevalence of modern anti-LGBT+ prejudice in HE and its negative impact on LGBT+ students. Qualitative results suggest that recognising LGBT+ social identity plays a key role in supporting LGBT+ students cope with negative campus climates. Increasing institutional support for intersectional LGBT+ student organisations, LGBT+ sensitivity training, and LGBT-inclusive policies are recommended for creating safer spaces for LGBT+ students.