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Category: Project

Description: Sickle cell disease is the most common monogenic condition in the world. Affected individuals are more susceptible to infections and hypercoagulability disorders. The pathophysiology of SARS-CoV-2 infection, on the other hand, encompasses several thrombotic and inflammatory events. Although several international health agencies have included people with sickle cell disease as part of the group at high risk for severe COVID-19 illness, the literature available about this topic is not completely systematized yet. Therefore, this project aims to understand and systematize the current state of scientific knowledge about the behavior of SARS-CoV-2 infection in individuals with sickle cell. This is an integrative systematic review of primary and secondary studies developed with qualitative, quantitative, or mixed methodologies in English, Spanish, or Portuguese, which portray the proposed theme. The research will be performed in three databases, based on descriptors chosen by the "Medical Subject Headings". We expect our results to contribute to the synthesis of scientific knowledge on this topic, helping to integrate understanding and thus help to identify gaps in the area.