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With the MINT study, we aim to investigate the potential effects of a 3% topical menthol gel as compared to a placebo gel in relieving CIPN symptoms in patients who have finished their chemotherapy at least three months before entering the study. Forty patients will be recruited and randomly assigned with a ratio of 1:1 to the placebo or the treatment group. They will be asked to apply their gel for a duration of 6 weeks. We will make use of several measurements including the Brief Pain Inventory (Short-Form), EORTC QLQ CIPN-20, Quantitative Sensory Testing, the Hospital Anxiety and Depression Scale, actigraphy and (functional) MRI to establish baselines and follow-up measures after 6 weeks. For the following 6 weeks no treatment will be given and at 12 weeks a second follow-up assessment (without (f)MRI) will be conducted.
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