The number of pupils identified with Special Educational Needs and Disabilities (SEND) continues to rise. Educational outcomes for those with SEND are often lower compared to those without SEND and this gap has become larger as a result of the COVID-19 pandemic. Thus, it is important for parents, educators, specialist professionals and policymakers to have an understanding of the best evidence-based practice to raise educational outcomes in pupils with SEND. The current study will synthesise evidence of what works across different pupils with SEND aged 4 to 25 in a systematic review followed by a meta-analysis (phase 1). In addition to analysis of the quality of the evidence base, this meta-analysis will, for the first time, inform which interventions work best (i.e., largest effect sizes) in relation to different phases of education (preschool, primary, secondary, post-16) and different educational contexts (special vs mainstream) for each category of SEND needs. In phase 2, we will identify barriers that educational professionals face in implementing the most effective practices indicated by the evidence through in-depth interviews. We will produce a toolkit featuring a database that can inform practitioners about the evidence-base underpinning different interventions for pupils with SEND and which interventions to select in different context according to the pupils’ needs. This will allow parents, educators, specialist professionals and policymakers to make evidence-informed decisions about how to raise educational outcomes for those with SEND in cost-effective ways and inform the future research agenda of academics and relevant funders. Project webpage: https://www.ucl.ac.uk/ioe/departments-and-centres/departments/psychology-and-human-development/child-development-and-learning-difficulties-lab/raising-educational-outcomes-pupils-sen-and-disabilities-metasense This project is funded by the Nuffield Foundation. The Nuffield Foundation is an independent charitable trust with a mission to advance social well-being. It funds research that informs social policy, primarily in Education, Welfare, and Justice. It also funds student programmes that provide opportunities for young people to develop skills in quantitative and scientific methods. The Nuffield Foundation is the founder and co-funder of the Nuffield Council on Bioethics, the Ada Lovelace Institute and the Nuffield Family Justice Observatory. The Foundation has funded this project, but the views expressed are those of the authors and not necessarily the Foundation. Visit www.nuffieldfoundation.org