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Description: **Abstract:** Cells that become permanently trapped in a specific stage of the cell cycle enter a state known as senescence, which is common in hepatocytes. These cells are often referred to as "zombie cells." When an entire organ is filled with these zombie cells, it is described as being in a "zombie-like" state, characterized by a significant loss of function. The senescence-associated secretory phenotype (SASP) includes various substances released by senescent cells, which can significantly affect neighboring cells and tissues. Although cellular senescence and SASP are interconnected concepts, they are distinct. This scoping review aims to clarify the roles of hepatocyte senescence and hepatocyte-SASP in the administration of pharmaceuticals and their relevance to forensic practice. We discuss the effects of pharmaceuticals on senescent hepatocytes, particularly focusing on the forensic implications of substances that are likely to be abused. In conclusion, hepatocyte senescence may play a crucial role in clinical and forensic contexts, as it offers new insights for interpreting clinical findings and expert witness testimony.